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ANDREA ISIDORI

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DIPARTIMENTO DI MEDICINA SPERIMENTALE

CURRICULUM DIDATTICO-SCIENTIFICO PROF. ANDREA M. ISIDORI

 


DATI PERSONALI

Nome e Cognome Andrea (M) Isidori
Luogo e data di nascita Roma, 8 Gennaio 1975
Dipartimento Medicina Sperimentale
Indirizzo Viale Regina Elena, 324
Telefono ufficio 0649970540
Fax 06490530
Settore Scientifico-Disciplinare MED/13


ATTUALE POSIZIONE

Professore Aggregato - Ricercatore in Endocrinologia/ MED 13 I Facoltà di Medicina e Chirurgia. Afferente al Dipartimento di Medicina Sperimentale – Sezione di Fisiopatologia Medica ed Endocrinologia.
Dirigente Medico nell’UOC IEC06. Endocrinologia, Andrologia e Medicina della Riproduzione.

CARRIERA E TITOLI

1999: Laurea in Medicina e Chirurgia, voto 110/110 e Lode, Università di Roma “Sapienza”.
2000: Honorary Clinical Assistant at St. Bartholomew’s Hospital, London, UK.
2002: Research Fellow at Queen Mary University of London, UK.
2004: Specializzazione in Endocrinologia e Malattie Metaboliche - I° Scuola di Endocrinologia e Malattie del Ricambio, Università di Roma “Sapienza”.
2008: Dottorato di Ricerca (PhD) in Scienze e Tecnologie Cellulari – Università di Roma “Sapienza”. 2008: Ricercatore in Endocrinologia/ MED 13 I Facoltà di Medicina e Chirurgia– Università di Roma “Sapienza”.

 

PREMI E RICONOSCIMENTI

1) 2002 Awarded with a Travel Grant (USD-1000) issued by the American Endocrine Society.
2) 2005 Winner of the “TRONCHETTI” Prize (€5000) issued by the Italian Society of Endocrinology (Società Italiana di Endocrinologia SIE) for the best research by investigators under the age of 30.
3) 2005 Winner of the “Pietrandrea” Prize (€2000) issued by the Rotary Club for the best publication from young investigators.
4) 2006 Winner of a Mobility (Exchange) Grant (€15000) for his international collaboration with the Endocrine Oncology Unit of the Queen Mary University of London, issued by the Italian Society of Endocrinology (Società Italiana di Endocrinologia SIE).
5) 2008 Awarded with a Travel Grant (€1000) from the International Society of Endocrinology for his oral presentation to the Conference in Rio the Janeiro.
6) 2012 Nominated Expert for the AIFA (Italian Regulatory Agency for Pharmaceutics)

ATTIVITA’ DIDATTICA

7) 2008-2010: attività di Docenza di Fisiologia, Anatomia e Istologia nel Corso di Laurea CLUPS Infermieristica
8) Dal 2006: partecipazione all’attività di Docenza nella I° Scuola di Specializzazione in Endocrionologia e Malattie del Ricambio.
9) Dal 2008: attività di Docenza nei corsi di Endocrinologia, Medicina della Riproduzione e Metodologia Medico-Scientifica presso la Facoltà di Medicina e Odontoiatria.

ATTIVITA’ SCIENTIFICA

Ricerca clinica e molecolare:
1. PRIN 2008 – Coordinatore Nazionale della Ricerca - Profilo molecolare, metabolico ed ormonale della progressione del tumore prostatico.
2. Ricerca Finalizzata Ministero Salute 2008 Progetto Strategico Salute della Donna – Responsabile Sottogruppo (IFO-San Gallicano) - Ormoni sessuali come determinanti “di genere” nella risposta immune e nello sviluppo di malattie autoimmuni e metaboliche.
3. FIRB 2010 – Accordi di Programma – Responsabilità Unità - The phosphodiesterase system as a pathophysiological target in cardiac hypertrophy: a molecular and functional study on the neuro-endocrine adaptive responses of cardiomyocytes.
4. Ricerche Universitarie Sapienza (ex Ateneo) 2008 - "Implicazioni del metabolismo intratissutale degli ormonali steroidei sull’acquisizione della competenza metastatica nel cancro prostatico: approccio bionanotecnologico nello studio dell’invasività tumorale."
5. Società Italiana di Endocrinologia – Endotrial – Studio di comparazione sugli inibitori delle fosfodiesterasi.

ATTIVITA’ ASSISTENZIALE

Dal 2004: Attività Assistenziale Ambulatoriale e di Diagnostica Strumentale (ecografie tiroidee, testicolare e prostatiche; aghi-aspirati eco-assistiti della tiroide) presso il Dipartimento di Medicina Sperimentale- Sezione di Fisiopatologia Medica dell’Università di Roma“Sapienza”, presso l’U.O.C. IEC 06 di Andrologia, Fisiopatologia della Riproduzione e Diagnosi Endocrinologiche diretta dal Prof Andrea Lenzi. Dal Dicembre 2010 – Dirigente Medico presso la IEC06 del DAI di Medicina Interna del Policlinico Umberto I.

PUBBLICAZIONI SCIENTIFICHE

Autore di oltre 60 pubblicazioni in extenso su riviste indicizzate peer-reviewed con Fattore di Impatto (IF) > 220; H-index: 24
Selected publications
1 Giannetta E, Isidori AM, Galea N, Carbone I, Mandosi E, Vizza CD, Naro F, Morano S, Fedele F, Lenzi A. Chronic Inhibition of Cyclic GMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy: A Randomized, Controlled Clinical Trial using Magnetic Resonance Imaging with Myocardial Tagging. Circulation. 2012 Apr 11. [Epub ahead of print] 14932
2 Saad F, Aversa A, Isidori AM, Gooren LJ. Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review. Curr Diabetes Rev. 2012 Mar;8(2):131-43.
3 De Larichaudy J, Zufferli A, Serra F, Isidori AM, Naro F, Dessalle K, Desgeorges M, Piraud M, Cheillan D, Vidal H, Lefai E, Némoz G. TNF-?- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism. Skelet Muscle. 2012 Jan 18;2(1):2.
 4 Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ. Onset of effects of testosterone treatment and time span until maximum effects are achieved. Eur J Endocrinol. 2011 Jul 13. [Epub ahead of print]  3482
 5 Giganti MG, Minella D, Testa B, Zenobi R, Biancolella M, Isidori AM, Caprio M, Novelli G, Fabbri A. A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011Apr-Jun;25(2):291-4.  2825
 6 Storr H, Alexandraki K, Martin L, Isidori AM, Kaltsas G, Monson J, Besser G, Matson M, Evanson J, Afshar F, Sabin I, Savage M, Grossman A. Comparisons in the epidemiology, diagnostic features and cure rate by transsphenoidal surgery between paediatric and adult-onset Cushing's disease. European Journal of Endocrinology.2011;164:667-674.  3482
 7 Aversa A, Bruzziches R, Francomano D, Rosano G, Isidori AM, Lenzi A, Spera G. Effects of Testosterone Undecanoate on Cardiovascular Risk Factors and Atherosclerosis in Middle-Aged Men with Late-Onset Hypogonadism and Metabolic Syndrome: Results from a 24-month, Randomized, Double-Blind, Placebo-Controlled Study. Journal of Sexual Medicine. 2010;7:3495-3503.  3957
 8 Isidori AM, Pozza C, Esposito K, Giugliano D, Morano S, Vignozzi L, Corona G, Lenzi A, Jannini EA. Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction. Journal of Sexual Medicine. 2010;7:1139-1146.  3957
 9 Isidori AM, Pozza C, Fierro F, Giannetta E, Bonifacio V, Manganaro L, Lenzi A. Use of contrast enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) in the characterization of non-palpable testicular lesions. International Journal of Andrology. 2010;33:60-60.  3601
 10 Radicioni AF, De Marco E, Gianfrilli D, Granato S, Gandini L, Isidori AM, Lenzi A. Strategies and advantages of early diagnosis in Klinefelter's syndrome. Molecular Human Reproduction. 2010; 16:434-440.  3506
11 Alexandraki KI, Kaltsas GA, Isidori AM, Akker SA, Drake WM, Chew SL, Monson JP, Besser MG, Grossman AB. The prevalence and characteristic features of cyclicity and variability in Cushing's disease. European Journal of Endocrinology. 2009;160:1011-1018.  3539
 12 Gianfrilli D, Isidori AM, Lenzi A. Segmental testicular ischaemia: presentation, management and follow-up. International Journal of Andrology. 2009;32:524-531.  3705
 13 Jannini EA, Isidori AM, Gravina GL, Aversa A, Balercia G, Bocchio M, Boscaro M, Carani C, Corona G, Fabbri A, Foresta C, Forti G, Francavilla S, Granata ARM, Maggi M, Mansani R, Palego P, Spera G, Vetri M, Lenzi A, Carosa E, Di Tommaso S, Bruzziches R, Francomano D, Gianfrilli D, Pozza C, Giannetta E, Selice R, Caretta N, Paggi F, Buldreghini E, Magini A, Krausz C, Caprio M, De Martino MU, Falcone S, Ruggiero A, Guidi A, De Mola G, Pugni V. The ENDOTRIAL Study: A spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction. Journal of Sexual Medicine. 2009;6:2547-2560.  4884
 14 Sookur PA, Sahdev A, Rockall AG, Isidori AM, Monson JP, Grossman AB, Reznek RH. Imaging in covert ectopic ACTH secretion: A CT pictorial review. European Radiology. 2009;19:1069-1078.  3589
 15 Isidori AM, Giannetta E, Lenzi A. Male hypogonadism. Pituitary. 2008;11:171-180.  2282
 16 Pierotti S, Gandini L, Lenzi A, Isidori AM. Pre-receptorial regulation of steroid hormones in bone cells: Insights on glucocorticoid-induced osteoporosis. Journal of Steroid Biochemistry and Molecular Biology. 2008;108:292-299. 2827 
 17 Isidori AM, Lenzi A. Testosterone replacement therapy: What we know is not yet enough. Mayo Clinic Proceedings. 2007;82:11-13.  4362
 18 Fabbri A, Isidori AM, Giannetta E, Lenzi A. Testosterone treatment to mimic hormone physiology in androgen replacement therapy: A view on testosterone gel and other preparations available. Expert Opinion on Biological Therapy. 2007;7:1093-1106.  2705
 19 Jannini EA, Lenzi A, Isidori A, Fabbri A. Subclinical erectile dysfunction: Proposal for a novel taxonomic category in sexual medicine. Journal of Sexual Medicine. 2006;3:787-794.  4676
 20 Isidori AM, Pozza C, Gianfrilli D, Isidori A. Medical treatment to improve sperm quality. Reproductive BioMedicine Online. 2006;12:704-714.  3206
 21 Isidori AM, Kaltsas GA, Pozza C, Frajese V, Newell-Price J, Reznek RH, Jenkins PJ, Monson JP, Grossman AB, Besser G. Extensive clinical experience - The ectopic adrenocorticotropin syndrome: Clinical features, diagnosis, management, and long-term follow-up. Journal of Clinical Endocrinology and Metabolism. 2006;91:371-377.  5799
 22 Isidori AM, Kaltsas GA, Grossman AB. Ectopic ACTH syndrome. In: Arzt E, Guitelman M, Bronstein M. eds. Front. Horm. Res. 2006;143-156. 1632 
 23 Dias R, Storr HL, Perry LA, Isidori AM, Grossman AB, Savage MO. The discriminatory value of the low-dose dexamethasone suppression test in the investigation of Paediatric Cushing's syndrome. Hormone Research. 2006;65:159-162.
 24 Woo YS, Isidori AM, Wat WZ, Kaltsas GA, Afshar F, Sabin I, Jenkins PJ, Monson JP, Besser GM, Grossman AB. Clinical and biochemical characteristics of adrenocorticotropin-secreting macroadenomas. Journal of Clinical Endocrinology and Metabolism. 2005;90:4963-4969.  6020
 25 Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, Jannini EA. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. Journal of Clinical Endocrinology and Metabolism. 2005;90:6472-6479.  6020
26 Isidori AM, Giannetta E, Gianfrilli D, Greco EA, Bonifacio V, Aversa A, Isidori A, Fabbri A, Lenzi A. Effects of testosterone on sexual function in men: Results of a meta-analysis. Clinical Endocrinology. 2005;63:381-394.  3412
 27 Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A, Fabbri A. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A meta-analysis. Clinical Endocrinology. 2005;63:280-293.
28 Isidori AM, Giannetta E, Pozza C, Bonifacio V, Isidori A. Androgens, cardiovascular disease and osteoporosis. Journal of Endocrinological Investigation. 2005;28:73-79.  1496
 29 Isidori AM, Greco EA, Aversa A. Androgen deficiency and hormone-replacement therapy. BJU International. 2005;96:212-216.  2247
 30 Isidori AM, Lenzi A. Risk factors for androgen decline in older males: lifestyle, chronic diseases and drugs. Journal of Endocrinological Investigation. 2005;28:14-22  1496
 31 Aversa A, Isidori AM, Gianfrilli D, Greco EA, Graziottin A, Zizzo G, Lenzi A, Fabbri A. Are subjects with erectile dysfunction aware of their condition? Results from a retrospective study based on an Italian free-call information service. Journal of Endocrinological Investigation. 2004;27:548-556.   1525
 32 Aversa A, Isidori AM, Greco EA, Giannetta E, Gianfrilli D, Spera E, Fabbri A. Hormonal Supplementation and Erectile Dysfunction. European Urology. 2004;45:535-538.  2651
 33 Kaltsas GA, Isidori AM, Besser GM, Grossman AB. Secondary forms of polycystic ovary syndrome. Trends in Endocrinology and Metabolism. 2004;15:204-210.  9058
 34 Lingam RK, Sohaib SA, Rockall AG, Isidori AM, Chew S, Monson JP, Grossman A, Besser GM, Reznek RH. Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). European Radiology. 2004;14:1787-1792.  2364
 35 Rockall AG, Babar SA, Aslam Sohaib SA, Isidori AM, Diaz-Cano S, Monson JP, Grossman AB, Reznek RH. CT and MR imaging of the adrenal glands in ACTH-independent cushing syndrome. Radiographics. 2004;24:435-452.  2494
 36 Storr HL, Isidori AM, Monson JP, Besser GM, Grossman AB, Savage MO. Prepubertal Cushing's disease is more common in males, but there is no increase in severity at diagnosis. Journal of Clinical Endocrinology and Metabolism. 2004;89:3818-3820.
 37 Aversa A, Isidori AM, Fabbri A, Slob AK. The limited practical value of color Doppler sonography in the differential diagnosis of men with erectile dysfunction' by Slob et al: A different point of view. International Journal of Impotence Research. 2003;15:385-387.  3063
 38 Aversa A, Isidori AM, Spera G, Lenzi A, Fabbri A. Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction. Clinical Endocrinology. 2003;58:632-638.  2767
 39 Caprio M, Fabbrini E, Ricci G, Basciani S, Gnessi L, Arizzi M, Carta AR, De Martino MU, Isidori AM, Frajese GV, Fabbri A. Ontogenesis of leptin receptor in rat Leydig cells. Biology of Reproduction. 2003;68:1199-1207.  3646
 40 Isidori AM, Kaltsas GA, Mohammed S, Morris DG, Jenkins P, Chew SL, Monson JP, Besser GM, Grossman AB. Discriminatory Value of the Low-Dose Dexamethasone Suppression Test in Establishing the Diagnosis and Differential Diagnosis of Cushing's Syndrome. Journal of Clinical Endocrinology and Metabolism. 2003;88:5299-5306.  5873
 41 Isidori AM, Kaltsas GA, Perry L, Burrin JM, Besser GM, Monson JP. The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism. Clinical Endocrinology. 2003;58:601-611.  2767
 42 Kaltsas GA, Isidori AM, Kola BP, Skelly RH, Chew SL, Jenkins PJ, Monson JP, Grossman AB, Besser GM. The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women. Journal of Clinical Endocrinology and Metabolism. 2003;88:2634-2643.  5873
43 Kaltsas GA, Mukherjee JJ, Kola B, Isidori AM, Hanson JA, Dacie JE, Reznek R, Monson JP, Grossman AB. Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women? Clinical Endocrinology. 2003;59:34-43.  2767
 44 Lingam RK, Sohaib SA, Vlahos I, Rockall AG, Isidori AM, Monson JP, Grossman A, Reznek RH. CT of primary hyperaldosteronism (Conn's syndrome): The value of measuring the adrenal gland. American Journal of Roentgenology. 2003;181:843-849.
45 Norman D, Isidori AM, Frajese V, Caprio M, Chew SL, Grossman AB, Clark AJ, Besser GM, Fabbri A. ACTH and a-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: Model for a central-peripheral melanocortin-leptin pathway. Molecular and Cellular Endocrinology. 2003;200:99-109  2637
 46 Rockall AG, Sohaib SA, Evans D, Kaltsas G, Isidori AM, Monson JP, Besser GM, Grossman AB, Reznek RH. Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome. European Journal of Endocrinology. 2003;149:561-567.  2941
 47 Rockall AG, Sohaib SA, Evans D, Kaltsas G, Isidori AM, Monson JP, Besser GM, Grossman AB, Reznek RH. Hepatic steatosis in Cushing's syndrome: A radiological assessment using computed tomography. European Journal of Endocrinology. 2003;149:543-548.  2941
 48 Aversa A, Isidori AM, Caprio M, Cerilli M, Frajese V, Fabbri A. Penile pharmacotesting in diagnosing male erectile dysfunction: Evidence for lack of accuracy and specificity. International Journal of Andrology. 2002;25:6-10.  1520
49 Isidori AM, Kaltsas GA, Korbonits M, Pyle M, Gueorguiev M, Meinhardt A, Metz C, Petrovsky N, Popovic V, Bucala R, Grossman AB. Response of serum macrophage migration inhibitory factor levels to stimulation or suppression of the hypothalamo-pituitary-adrenal axis in normal subjects and patients with Cushing's disease. Journal of Clinical Endocrinology and Metabolism. 2002;87:1834-1840.  5199
 50 Isidori AM, Kaltsas G, Frajese V, Kola B, Whitelocke RAF, Plowman PN, Britton KE, Monson JP, Grossman AB, Besser GM. Ocular metastases secondary to carcinoid tumors: The utility of imaging with 123meta-iodobenzylguanidine and 111In-DTPA pentetreotide. Journal of Clinical Endocrinology and Metabolism. 2002;87:1627-1633.  5199
 51 Kaltsas GA, Mukherjee JJ, Isidori A, Kola B, Plowman PN, Monson JP, Grossman AB, Besser GM. Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil. Clinical Endocrinology. 2002;57:169-183.  2674
 52 Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A. Leptin in reproduction. Trends in Endocrinology and Metabolism. 2001;12:65-72.  5823
 53 Kaltsas GA, Isidori AM, Florakis D, Trainer PJ, Camacho-Hubner C, Afshar F, Sabin I, Jenkins JP, Chew SL, Monson JP, Besser GM, Grossman AB. Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity. Journal of Clinical Endocrinology and Metabolism. 2001;86:1645-1652.  5160
 54 Aversa A, Isidori AM, De Martino MU, Caprio M, Fabbrini E, Rocchietti-March M, Frajese G, Fabbri A. Androgens and penile erection: Evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clinical Endocrinology. 2000;53:517-522.  2922
 55 Aversa A, Mazzilli F, Rossi T, Delfino M, Isidori AM, Fabbri A. Effects of sildenafil (Viagra(TM)) administration on seminal parameters and post-ejaculatory refractory time in normal males. Human Reproduction. 2000;15:131-134.  2997
 56 Isidori AM, Strollo F, Morè M, Caprio M, Aversa A, Moretti C, Frajese G, Riondino G, Fabbri A. Leptin and aging: Correlation with endocrine changes in male and female healthy adult populations of different body weights. Journal of Clinical Endocrinology and Metabolism. 2000;85:1954-1962.  5447
 57 Kaltsas GA, Korbonits M, Isidori AM, Webb JAW, Trainer PJ, Monson JP, Besser GM, Grossman AB. How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome? Clinical Endocrinology. 2000;53:493-500.  2922
 58 Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, Fabbri A. Leptin and androgens in male obesity: Evidence for leptin contribution to reduced androgen levels.. Journal of Clinical Endocrinology and Metabolism. 1999;84:3673-3680.  5447
 59 Caprio M, Isidori AM, Carta AR, Moretti C, Dufau ML, Fabbri A. Expression of functional leptin receptors in rodent Leydig cells. Endocrinology. 1999;140:4939-4947.  4790
 60 Fabbri A, Aversa A, Isidori A. Sildenafil and erectile dysfunction. Journal of endocrinological investigation. 1999;22:486-491.   1398
61 Fabbri A, Giannini D, Aversa A, De Martino MU, Fabbrini E, Franceschi F, Moretti C, Frajese G, Isidori A. Body-fat distribution and responsiveness of the pituitary-adrenal axis to corticotropin-releasing-hormone stimulation in sedentary and exercising women. Journal of endocrinological investigation. 1999;22:377-385. 

 

LIBRI (max 5)

- Andrea M Isidori & Andrea Lenzi. Scrotal Ultrasound: morphological and functional atlas. Published by the National Academy of Medicine (ANM). Genoa 2008. 183 pages.

- Andrea. M. Isidori & Andrea Lenzi. Edizione Italiana di Andrologia Clinica (Andrology for the Physician, Schill-Comaire). Springer Verlag Berlin 2010. 647 pages.

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